This considers is to execute Busy Picture in study vocabulary to improve students’ vocabulary mastery. The point of this investigate is to discover out whether the busy picture effective to imporve students’ vocabulary at the second semester students Faculty of Engineering Muhammadiyah University of Makassar. This investigate employments Pre-Experimental Research and pre-test and post-test as the instrument to gather the information. The overall numbers of population are 120 students with 30 students as sample. This investigates employments cluster random sampling to select one of the four classes. The data analyzed obtained from the students’ answers in pre-test and post-test.  After applying treatment, the students’ in vocabulary mastery increased. The result in this investigation is the students’ mean score of pre-test was 65.5 which classified into fairly category and post-test was 85 which classified into good category.. Using the Busy Picture as media to teaching and learning vocabulary helped the students memorizing vocabulary and it was easy to applying in the class. The result of this investigation will be valuable within the future