To prepare the 21st-century generation, scientific literacy are part of 21st-century education that students must possess. This study aims to develop water teaching materials using Smart Apps Creator 3 on students’ scientific literacy with a learning model of the Science, Technology, Religious, Engineering, Art, and Mathematics (STREAM) approach in online learning. SAC 3 -based interactive multimedia is used for learning media and understanding science subjects about water. Scientific literacy competencies include explaining problems, planning investigations, conducting investigations, interpreting data, evaluating investigations, and communicating information which is all carried out scientifically. The experimental method carried out by R and D uses the 4D design (Define, Design, Develop and Disseminate). The research data were collected and analyzed in the form of quantitative descriptive from the results of the students’ pretest and posttest. This research was conducted through a google form by distributing a questionnaire, which was given to students at MTs Al-Ma’tuq Putri Sukabumi with 30 respondents and five science teachers who had used STREAM-based water teaching materials using SAC 3. The results of the study, the average percentage of scientific literacy with N Gain was 65% with a moderate category, which means that the application of learning materials based on SAC 3 is proven to improve student learning. This study’s conclusion shows that learning using STREAM-based teaching materials using SAC 3 is statistically very significant, proven to be effective in improving students’ scientific literacy skill to water material in online learning during the current pandemic.